FERTILITY PRESERVATION IN ADULT LYMPHOMA PATIENTS: A CONSENSUS‐BASED POSITION PAPER BY THE FONDAZIONE ITALIANA LINFOMI (FIL) & SOCIETà ITALIANA DELLA RIPRODUZIONE UMANA (SIRU)

Background: In this consensus-based position paper, the scientific societies Fondazione Italiana Linfomi (FIL) and Società della Riproduzione Umana (SIRU) reviewed main aspects identified optimal paths aimed to preserve monitor fertility in patients diagnosed with lymphoma. Methods: The multi-disciplinary working group for paper was composed by 5 onco-hematologists, 4 gynecologist or andrologists, 1 embryologist biologist, supervision of an international expert leader. A series rank-ordering key questions were proposed according clinical relevance focusing on non-Hodgkin's lymphomas Hodgkin agreement among all Panelists scored a web-based questionnaire Delphi methodology (two rounds). All statements newly discussed round robin way confirmed drafting final recommendations. Results: Chemotherapy-induced gonadotoxicity is influenced type agent, dose intensity (high risk infertility ≥80%, intermediate 40%–60%, low <20%, very unknown risk, women, also age at treatment. correct timing onco-fertility counseling as soon possible, ideally time diagnosis, order increase patient’s awareness allow optimization apply FP techniques. An urgent referral pathway needs be established between Hematological Reproductive Centers aim offer within 24–48 h. Blood specialist exams performed during pre-therapy have been summarized. Oocyte cryopreservation well-established technique that should after personalized counseling, possibility delay treatment 10–14 days. Ovarian tissue could unique with: therapeutic urgency, when chemotherapy has started day, there high/moderate gonadotoxic if patient's conditions are feasible surgery. To improve safety ovarian transplantation complete prolonged survival lymphoma, samples analyzed exclude presence neoplastic cells using molecular histological analyses prior graft, especially aggressive NHL histotypes. Post-pubertal males offered sperm cryopreservation. GnRHa not considered alternative option techniques unless women whom these latter contraindicated due start issues. Indications tests carried out period following (1–5 years >5 years) discussed. Conclusion: These recommendations would useful clinicians who take care young lymphoma guarantee evidence-based assessment oncologic pathway. research funded by: Ministry Health, Italian Government, R.C. funds 2022, IRCCS Istituto Tumori “Giovanni Paolo II,” Bari-Italy. Keywords: Late Effects Lymphoma Survivors No conflicts interests pertinent abstract.